Ssa Antibody Range

Ss b la antibodies are found primarily in patients with sjogren syndrome or le where they occur with frequencies of approximately 60 and 15 respectively 1 2 ss b la antibodies occur only infrequently in the absence of ss a ro antibodies.

Ssa antibody range.

Anti ro ssa is produced in the cytoplasm of cells in the epidermal layer of the skin following uv irradiation. The ssa antibody is usually found with the ssb antibody which means there is typically an anti ssb blood test ordered with the anti ssa test. Lupus erythematosus le 40 60 of. Antibodies to ena are common in patients with connective tissue diseases systemic rheumatic diseases.

It is not a specific enough test to determine a definitive diagnosis in a majority of patients but it can be used with other tools and tests to determine if lupus is present. Lower likelihood of anti dna antibodies. The presence of both antibodies ss a and ss b strengthen the diagnosis of sjögren s syndrome and conveys prognostic information. Patients with ss a may also have antibodies to cardiolipin lupus anticoagulant and clinical thromboses.

Ss b la is composed of a 48 kd protein combined with rna species. Anti ss a and anti ss b are found in virtually all children with neonatal lupus. Anti ro52 antibodies in particular have been tied to elevated photosensitivity. Ss a ro is composed of protein antigens of 52 kd and 60 kd combined with cytoplasmic rna species.

Age older than 50 years. Sjögren s antibody ss b is present only if sjögren s antibody ss a is also detected. Ss a ro ss b la rnp and sm are autoantigens commonly referred to as extractable nuclear antigens ena. Ss a ro antibodies occur in patients with several different connective tissue.

When anti ssa levels are elevated in sle it is often in antinuclear antibody ana negative lupus. Anti ro antibodies also known as anti ssa antibodies are associated with sjögren syndrome. This has been termed antiphospholipid antibody syndrome. Anti ssa plus anti la ssb is associated with the following factors.

Antibodies to ss a are also associated with hla loci dr3 and dr2 and with hereditary deficiency of c2. Ss a ro is an extractable nuclear antigen ena composed of protein antigens of 52 kd and 60 kd combined with cytoplasmic rna species. The reference range of anti ro antibodies is negative. Both anti ssa and anti ssa are usually absent in secondary sjögren s syndrome.

Sjogren s antibodies ss a ss b sjögren s antibodies ss b is detected in approximately 15 of patients with sjögren s syndrome.